Dasision study cml healthcare

Study Design for Newly Diagnosed Patients | SPRYCEL-hcp.com

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Head-to-Head Trial Design: SPRYCEL ® (dasatinib) vs Imatinib. Return to: Efficacy . DASISION Trial: SPRYCEL vs Imatinib Study in Treatment-Naïve CP Ph+ CML Adult Patients 1,2. Primary endpoint: cCCyR a by 12 months 2 Select secondary endpoints included: MMR b at any time, time to MMR, and time to cCCyR 2 Patients with a history of cardiac disease were included in this study, except those …

Study Design for Newly Diagnosed Patients | SPRYCEL-hcp.com

SPRYCEL (dasatinib) for Healthcare Professionals

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SPRYCEL ® (dasatinib) is indicated for the treatment of adults with: Newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) in chronic phase; Chronic, accelerated, or myeloid or lymphoid blast phase Ph+ CML with resistance or intolerance to …

SPRYCEL (dasatinib) for Healthcare Professionals

Be Chronic Myeloid Leukemia (CML) Informed

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Data come from a retrospective cohort study of patients newly diagnosed with CML in the US who were initiating first-line TKI therapy (N=1431). 5 This study is subject to several limitations due to the data sources. The data come from a commercial insurance database, which …

Be Chronic Myeloid Leukemia (CML) Informed

Sprycel Shows Promise as First Line Therapy for CML ...

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The results from the 18 month Phase III DASISION study look very promising for Sprycel as an effective first-line therapy treatment. The DASISION study enrolled 519 newly diagnosed chronic phase ph+ Chronic Myeloid Leukemia patients. The trial provided 259 randomized patients with 100 mg of Sprycel once daily, and the other 260 patients received 400mg of imatinib once daily.

Sprycel Shows Promise as First Line Therapy for CML ...

Sprycel Shows Promise as a First Line Therapy - Chronic ...

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The results from the 18 month Phase III DASISION study look very promising for Sprycel as an effective first-line therapy treatment. The DASISION study enrolled 519 newly diagnosed chronic phase ph+ Chronic Myeloid Leukemia patients. The trial provided 259 randomized patients with 100 mg of Sprycel once daily, and the other 260 patients received 400mg of imatinib once daily.

Sprycel Shows Promise as a First Line Therapy - Chronic ...

Efficacy and safety of dasatinib versus imatinib in the ...

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In the phase 3 DASISION trial (Dasatinib Versus Imatinib Study In Treatment-Naive Chronic Myeloid Leukemia), patients with newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) were randomized to receive first-line treatment with either dasatinib 100 …

Efficacy and safety of dasatinib versus imatinib in the ...

FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult ...

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10/28/2010 · About the DASISION Study. DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CP-CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily vs. imatinib 400 mg taken once daily, in …

FDA Approves SPRYCEL® (dasatinib) as Treatment for Adult ...

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

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12/6/2010 · About the DASISION Study. DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CP-CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily vs. imatinib 400 mg taken once daily, in …

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

CML Updates: Defining MMR and Results of the DASISION Trial

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In his talk, “Final study results of the phase 3 dasatinib versus imatinib in newly diagnosed chronic myeloid leukemia in chronic phase (CML-CP) trial (DASISION, CA180-056),” he reported the ...

CML Updates: Defining MMR and Results of the DASISION Trial

Long-term dasatinib findings support first-line use in CML

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6/15/2016 · Final DASISION study findings confirm dasatinib to be an effective, long-term treatment for patients with a new diagnosis of chronic phase-chronic myeloid leukaemia (CP-CML). After 5 …

Long-term dasatinib findings support first-line use in CML

Imatinib is still recommended for frontline therapy for CML

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Data from the IRIS trial and CML Study IV, each with more than 10 years of follow-up, established ... The ENESTnd, DASISION, and BFORE trials were the primary registration trials for the frontline ... healthcare system,cost-effectiveness analysescontinue toshow

Imatinib is still recommended for frontline therapy for CML

Lymphocytosis after treatment with dasatinib in chronic ...

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5/1/2016 · The proliferation of clonal cytotoxic T‐cells or natural killer cells has been observed after dasatinib treatment in small studies of patients with chronic myeloid leukemia (CML). (a,b) The treatment of a woman who had imatinib‐resistant, blast‐phase chronic myeloid leukemia with splenomegaly ...

Lymphocytosis after treatment with dasatinib in chronic ...

CML Updates: Defining MMR and Results of the DASISION Trial

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1/19/2015 · Healthcare Costs in Need of Solutions: Experts at ASH Agree ... presented results from the DASISION trial. In his talk, “Final Study Results of the Phase 3 Dasatinib Versus Imatinib in Newly ...

CML Updates: Defining MMR and Results of the DASISION Trial

First-line treatment for chronic myeloid leukemia ...

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11/26/2010 · Imatinib, a tyrosine kinase inhibitor (TKI) of BCR-ABL, was the standard first-line therapy for chronic myeloid leukemia (CML) for almost 10 years. Dasatinib and nilotinib, two newer drugs with higher potency than imatinib against BCR-ABL and activity against most imatinib-resistant BCR-ABL mutations, have each shown superior efficacy compared with imatinib for first-line treatment of chronic ...

First-line treatment for chronic myeloid leukemia ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

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DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 mg taken once daily with no food restrictions ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

BCR-ABL1 mutation development during first-line treatment ...

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6/29/2015 · BCR-ABL1 mutations are a common, well-characterized mechanism of resistance to imatinib as first-line treatment of chronic myeloid leukemia in chronic phase (CML …

BCR-ABL1 mutation development during first-line treatment ...

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

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This study, known as DASISION, compared the investigational use of SPRYCEL versus Gleevec as a first-line treatment for patients with chronic phase chronic myeloid leukemia (CML-CP).

SPRYCEL® (dasatinib) Demonstrates Superior Confirmed ...

Lymphocytosis after treatment with dasatinib in chronic ...

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Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity. Authors. Charles A. Schiffer MD, ... CML-AP and CML-MBP, were no longer receiving dasatinib at that time (median on-treatment follow-up, 6.1 months). In the DASISION study, lymphocytosis was observed in 35% and 8% of dasatinib- and ...

Lymphocytosis after treatment with dasatinib in chronic ...

Final 5-Year Study Results of DASISION: The Dasatinib ...

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Request PDF on ResearchGate | Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naive Chronic Myeloid Leukemia Patients Trial | …

Final 5-Year Study Results of DASISION: The Dasatinib ...

Cardiovascular, pulmonary, and metabolic toxicities ...

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1. Introduction. Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm driven by constitutive activation of the BCR-ABL1 oncogene [1,2].The incidence of CML increases with age and is estimated to occur in 1.75/100,000 people in the United States [].Tyrosine kinase inhibitors (TKIs) are the mainstay of treatment for CML [4,5].In fact, it is projected that 181,000 patients will have ...

Cardiovascular, pulmonary, and metabolic toxicities ...

Lymphocytosis after treatment with dasatinib in chronic ...

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Lymphocytosis after treatment with dasatinib in chronic myeloid leukemia: Effects on response and toxicity ... low-up, 6.1 months). In the DASISION study, lympho- ... UDG Healthcare plc, funded by ...

Lymphocytosis after treatment with dasatinib in chronic ...

Michael J. Mauro MD - Healing, Teaching & Discovery

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Second and Third Generation TKIs for CML Compound‐Specific Toxicities of TKIs in CML. Michael J. Mauro MD. IRIS 8‐Year Update – 37%* Unacceptable Outcome ... DASISION Study…

Michael J. Mauro MD - Healing, Teaching & Discovery

Chronic myeloid leukaemia | Long-term dasatinib findings ...

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medwireNews: Final DASISION study findings confirm dasatinib to be an effective, long-term treatment for patients with a new diagnosis of chronic phase–chronic myeloid leukaemia (CP–CML). After 5 years, 61% of 259 patients randomly assigned to receive dasatinib 100 mg/day were still taking the ...

Chronic myeloid leukaemia | Long-term dasatinib findings ...

FDA approves U.S. product labeling update for Sprycel ...

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6/20/2013 · About the DASISION Study (CA180-056) DASISION is an open-label, randomized, Phase 3 international trial of Sprycel 100 mg taken once-daily vs. imatinib 400 mg taken once-daily, in the treatment of newly-diagnosed CP Ph+ CML. The study enrolled 519 patients; 259 patients were randomized to receive Sprycel and 260 patients were randomized to ...

FDA approves U.S. product labeling update for Sprycel ...

The relative efficacy of imatinib, dasatinib and nilotinib ...

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2/19/2013 · Dasatinib 100 mg daily and nilotinib 600/800 mg daily have been compared to imatinib as first line treatments for CML in two recent randomised studies. However, no head to head evidence exists of the relative efficacy of dasatinib and nilotinib. We conducted a systematic literature review and used the data extracted to perform an indirect comparison meta-analysis of the three interventions.

The relative efficacy of imatinib, dasatinib and nilotinib ...

Chronic myeloid leukemia: 2016 update on diagnosis ...

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1/22/2016 · Chronic Myeloid Leukemia (CML) is a myeloproliferative neoplasm with an incidence of one to two cases per 100,000 adults. ... Similar to the results of the DASISION study, ... This may represent a considerable burden on patients and the healthcare systems in relation to drug availability, compliance, potential development of long‐term side ...

Chronic myeloid leukemia: 2016 update on diagnosis ...

HCP Information | Manage Pleural Effusion

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*DASISION (DAsatinib versus Imatinib Study in Treatment-Naïve CML) is an open-label, randomised, multicentre phase III trial comparing long-term efficacy and safety of SPRYCEL (n=259) to imatinib (n=260) in adults with CP-CML. Primary endpoint was confirmed CCyR by 12 months and was found to be 77% SPRYCEL vs. 66% imatinib (p0.007). 4

HCP Information | Manage Pleural Effusion

POST-ASH Issue 4, 2015 - Research To Practice

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This activity will assist medical oncologists, hematologists, hematology-oncology fellows and other healthcare professionals in the ... chronic myeloid leukemia (CML), and as such I met with one of the research giants in the field, Dr Jorge Cortes, who ... POST-ASH Issue 4, 2015. fatigue and other related symptoms was observed with the use of rux.

POST-ASH Issue 4, 2015 - Research To Practice

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

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12/6/2010 · DASISION (Dasatinib versus Imatinib Study in Treatment-Naïve CP-CML Patients) is an open-label, randomized, Phase 3 international trial of SPRYCEL 100 …

Follow-Up Results from Study Comparing SPRYCEL® (dasatinib ...

BCR-ABL1 tyrosine kinase inhibitors for the treatment of ...

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The management of chronic myeloid leukemia with BCR-ABL1 tyrosine kinase inhibitors has evolved chronic myeloid leukemia into a chronic, manageable disease. A patient-centered approach is important for the appropriate management of chronic myeloid leukemia and optimization of long-term treatment outcomes. The pharmacist plays a key role in treatment selection, monitoring drug–drug ...

BCR-ABL1 tyrosine kinase inhibitors for the treatment of ...

Molecular Monitoring of Response In Patients With Chronic ...

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About Chronic Myeloid Leukemia. CML is a slow-growing type of leukaemia in which the body produces an uncontrolled number of abnormal white blood cells.[7] CML accounts for 15% of all leukaemias.[8] The incidence is estimated at 1-2 cases per 100,000.[9] CML occurs when pieces of two different chromosomes (9 and 22) break off and attach to each ...

Molecular Monitoring of Response In Patients With Chronic ...

DASISION | Access CML Drugs

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Bristol-Myers Squibb Company and Otsuka America Pharmaceutical, Inc. announced four-year follow-up data from the Phase III DASISION study of Sprycel...

DASISION | Access CML Drugs

Update on DASISION trial of Sprycel for PH-CP-CML- BMS ...

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Bristol-Myers Squibb Company and Otsuka America Pharmaceutical, Inc. announced four-year follow-up data from the Phase III DASISION study of Sprycel...

Update on DASISION trial of Sprycel for PH-CP-CML- BMS ...

Update on DASISION trial of Sprycel for PH-CP-CML- BMS ...

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12/5/2015 · Is there a best TKI for this patient with newly diagnosed chronic myeloid leukemia (CML) in chronic phase? ... In the multi-arm German CML IV study, ... financial impact of this extremely expensive therapy for individual patients as well as for entire healthcare systems has been raised by hematologists who treat this disease. 39 It has been ...

Update on DASISION trial of Sprycel for PH-CP-CML- BMS ...

Is there a best TKI for chronic phase CML? - Hematology

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The expanding options for front-line treatment in patients with newly diagnosed CML. Author links open overlay panel Javier Pinilla-Ibarz a Ian Flinn b. Show more. ... The phase 3, randomized Dasatinib vs Imatinib Study in Patients With Newly Diagnosed CML-CP (DASISION) ...

Is there a best TKI for chronic phase CML? - Hematology
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